2-methacryloyloxyethyl phosphorylcholine synthesis
- Product Name:2-methacryloyloxyethyl phosphorylcholine
- CAS Number:67881-98-5
- Molecular formula:C11H22NO6P
- Molecular Weight:295.27
![2-Propenoic acid, 2-methyl-, 2-[(2-oxido-1,3,2-dioxaphospholan-2-yl)oxy]ethyl ester](/CAS/20200515/GIF/82793-19-9.gif)
Yield:67881-98-5 3.1 g
Reaction Conditions:
in acetonitrile at -20 - 60; for 16 h;Sealed tube;
Steps:
4.2
(2) Take 5.0 g of OPEMA was dissolved in 30 mL of anhydrous acetonitrile and placed in a 200 mL glass pressure-resistant bottle. After cooling to -20 ° C, 2 mL of anhydrous trimethylamine was quickly added thereto. The pressure-resistant bottle was sealed, and the mixture was heated to 60 ° C for 16 hours, and then cooled to -20 ° C. The precipitated white solid was filtered under an argon atmosphere, and then dried under reduced pressure to give MPC (Compound 4, 3.1 g).
References:
Zhongshan Wan Han Pharmaceutical Co., Ltd.;Xiang Fei;Du Zhibo;Peng Wei CN108578390, 2018, A Location in patent:Paragraph 0111-0112; 0115
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