2-METHYL-1-PHENYL-1-BUTANOL synthesis
- Product Name:2-METHYL-1-PHENYL-1-BUTANOL
- CAS Number:3968-86-3
- Molecular formula:C11H16O
- Molecular Weight:164.24
Yield:3968-86-3 90%
Reaction Conditions:
with C24H24IrN4O4(1+)*BF4(1-);sodium t-butanolate at 140; for 24 h;Sealed tube;Inert atmosphere;
Steps:
General procedure for bis-NHC-Ir-catalyzed β-methylationof secondary alcohols
General procedure: To a sealed tube (35 mL)equipped with a stir bar, Ir-NHC catalyst 5d (0.1 mol%)methanol (1 mL), tBuONa (3 mmol) and primary alcohol(1 mmol) were added under nitrogen atmosphere. The solutionwas heated at 140 °C for 24 h. 1,3,5-Trimethoxybenzenewas added as an internal standard, and sent forNMR measurement. Pure products were obtained by columnchromatography over silica gel using ethyl acetate/petroleumether mixture as eluent.
References:
Lu, Zeye;Zheng, Qingshu;Zeng, Guangkuo;Kuang, Yunyan;Clark, James H.;Tu, Tao [Science China Chemistry,2021,vol. 64,# 8,p. 1361 - 1366]
