2-methyl-5-phenyl-2h-tetrazole synthesis
- Product Name:2-methyl-5-phenyl-2h-tetrazole
- CAS Number:20743-49-1
- Molecular formula:C8H8N4
- Molecular Weight:160.18
18039-42-4
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20743-49-1
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$336.00/1g
Yield:20743-49-1 77%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 12 h;Inert atmosphere;
Steps:
107 Synthesis of compound 107.1.
Into a 8-mL vial purged and maintained with an inert atmosphere of nitrogen, was placed 5-phenyl-2H-1,2,3,4-tetrazole (450 mg, 3.08 mmol, 1 equiv), DMF (5 mL), K2CO3 (851.1 mg, 6.16 mmol, 2 equiv), CH3I (437.0 mg, 3.08 mmol, 1 equiv), followed by stirring at room temperature for 12 h. The reaction mixture was then quenched by the addition of 10 mL of water and extracted with ethyl acetate (3 x 10 mL). The combined organic layers were concentrated under vacuum. The residue was applied onto a silica gel column with dichloromethane/methanol (80:1). This resulted in 380 mg (77.0%) of 107.1 as a white solid.
References:
WO2020/97408,2020,A1 Location in patent:Paragraph 00409
67-56-1
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18039-42-4
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20743-49-1
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$336.00/1g
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18039-42-4
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20743-49-1
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$336.00/1g
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616-38-6
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20743-50-4
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20743-49-1
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$336.00/1g
18039-42-4
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20743-49-1
8 suppliers
$336.00/1g