2-Methylindoline synthesis
- Product Name:2-Methylindoline
- CAS Number:6872-06-6
- Molecular formula:C9H11N
- Molecular Weight:133.19
131880-76-7
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54813-73-9
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6872-06-6
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$5.00/5g
Yield:6872-06-6 90% ，54813-73-9 10%
Reaction Conditions:
with triethyl borane;Triethoxysilane;sodium hydroxide in hexane at 80; for 6 h;Inert atmosphere;Sealed tube;Reagent/catalyst;Solvent;
Steps:
19 Example 19
Under argon atmosphere, NaOH and triethyl boron were first stirred at room temperature to form a clear clear solution at a concentration of 1 M / L;Subsequently, 10 mol (2 mol%) of the above-mentioned triethylboron solution, 5 mmol of amide substrate, 15 mmol of silane, 2 mL of solventInto a 10 mL sealed tube and placed in an oil bath at 80 ° C for 6 hours with heating. The reaction was completed and the reaction was exposed to air quenching, followed byThe yield was determined by column chromatography and gas chromatography and a pure product was obtained. When using polymethylhydrogensiloxane (PMHS) andTetrahydrofuran as silane and solvent, respectively, the yield of products A, B were: 72%, 11%; when the use of triethoxysilaneThe yield of the products A and B is 90% and 10%, respectively, when the alkyl and n-hexane are used as silane and solvent, respectively.
References:
CN107235845,2017,A Location in patent:Paragraph 0090; 0091; 0092; 0093
1516-96-7
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6872-06-6
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95-20-5
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6872-06-6
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50419-58-4
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6872-06-6
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