2-Methylthio-4-pyrimidinol synthesis
- Product Name:2-Methylthio-4-pyrimidinol
- CAS Number:5751-20-2
- Molecular formula:C5H6N2OS
- Molecular Weight:142.18
Yield:5751-20-2 93%
Reaction Conditions:
with tetrabutylammomium bromide;potassium carbonate at 120; for 8 h;
Steps:
1.1 Example 1
Step 1. Preparation of 2-methylthio-4-pyrimidinone: 128 g of thiouracil, 500 g of dimethyl carbonate, 300 g of potassium carbonate, 1 g of tetrabutylammonium bromide, and heated to 120° for 8 hours, after the reaction, ,Cooled to room temperature, filtered, and the filtrate was decompressed to recover unreacted dimethyl carbonate. The residue was added to 300 ml of water and extracted with 300 ml of ethyl acetate and dried.Filtration, the filtrate was added to 100 ml of petroleum ether was recrystallized to give 132g of a white powder, yield 93%;
References:
Shanghai Weiju Industrial Co., Ltd.;Liu Hui CN107488175, 2017, A Location in patent:Paragraph 0008; 0010
