2-MORPHOLINO-3-PYRIDINAMINE synthesis
- Product Name:2-MORPHOLINO-3-PYRIDINAMINE
- CAS Number:51627-47-5
- Molecular formula:C9H13N3O
- Molecular Weight:179.22
24255-27-4
64 suppliers
$16.00/250mg
51627-47-5
56 suppliers
$32.00/250mg
Yield:51627-47-5 90.1%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20; for 10 h;Solvent;
Steps:
6.B
4-(3-Nitropyridin-2-yl)morpholine (11.0 g, 52.6 mmol) was dissolved in methanol (100 mL)Add 10% palladium on carbon (5.6 g, 5.3 mmol),Hydrogen was introduced and reacted at room temperature for 10 h.After the reaction is completed, the solvent is distilled off under reduced pressure.The residue was dissolved in water (100 mL).Extracted with ethyl acetate (100 mL×3),The organic phase was collected and dried over anhydrous sodium sulfate.The solid was filtered off, and the solvent was evaporated under reduced pressure.The residue was passed through a silica gel column (mobile phase: PE: EA = 10:1).2-morpholinopyridine-3-amine gray solid 8.5 g was obtained in a yield of 90.1%.
References:
CN107840820,2018,A Location in patent:Paragraph 0018; 0028; 0038; 0048; 0058; 0065; 0067; 0068
39856-57-0
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51627-47-5
56 suppliers
$32.00/250mg
5470-18-8
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$6.00/5g
51627-47-5
56 suppliers
$32.00/250mg
110-91-8
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$9.00/1g
6298-19-7
511 suppliers
$6.00/5g
51627-47-5
56 suppliers
$32.00/250mg