2-Nitroacetophenone synthesis
- Product Name:2-Nitroacetophenone
- CAS Number:577-59-3
- Molecular formula:C8H7NO3
- Molecular Weight:165.15
98-86-2
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Yield:577-59-3 97%
Reaction Conditions:
with calcium silicate;sulfuric acid;nitric acid at -15;
Steps:
1.1 Step 1: Synthesis of 2'-nitroacetophenone
100 g of acetophenone is slowly added into a mixture of 500 ml of sulfuric acid and nitric acid (concentrated sulfuric acid and concentrated nitric acid in a volume ratio of 1:7 and a temperature of -15°C), and then 90 g of calcium silicate powder (14 g) is added (acetophenone and silicic acid). The weight ratio of calcium powder is 1:0.14).Keep stirring below -15°C overnight, then add ice water and filter to obtain 2-nitroacetophenone 134g as a yellow solid, yield 97%, purity 99.8%, MS: m/z=165 (M+), elemental analysis: C58.1% (theoretical 58.2%), H4.2% (theoretical 4.2%), O 29.0% (theoretical 29.1%), N8.4% (theoretical 8.5%), confirmed by molecular weight and elemental analysis 2'-nitroacetophenone.
References:
Shanghai Titan Technology Co., Ltd.;Xie Yingbo;Zhang Qing;Zhang Hua;Xu Xiaobing;Luo Guiyun CN105198813, 2018, B Location in patent:Paragraph 0016; 0019; 0020
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