2-Nitrofluorene synthesis
- Product Name:2-Nitrofluorene
- CAS Number:607-57-8
- Molecular formula:C13H9NO2
- Molecular Weight:211.22
86-73-7
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$6.00/25g
607-57-8
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$16.00/5g
Yield:607-57-8 92%
Reaction Conditions:
with nitric acid;acetic acid at 60; for 0.166667 h;
Steps:
2-Nitro-9H-fluorene (3)
9H-Fluorene (6.0 g, 36.1 mmol)was dissolved in 100 mL of glacial acetic acid at 60 °C. 15 mLof nitric acid (65%) were added dropwise (~10 min) at 60 °Cupon vigorous stirring. After the addition was completed, theresulting mixture was further stirred at 60 °C. The reaction wasmonitored by TLC (solvent EtOAc-n-heptane 1:9). After appearance of the spot of the dinitro product (≈100 min, Rf≈25%), the mixture was poured into 600 mL of water. The resulting crude product was filtered off, washed with water andrecrystallized from 200 mL acetonitrile to give compound 3(7.1 g, 92%) as slightly-yellow needles. 1H NMR (CDCl3,400 MHz) δ8.42 (s, 1H), 8.31 (d, J= 8.4 Hz, 1H), 7.89-7.87(m, 2H), 7.64 (d, J= 6.4 Hz, 1H), 7.49-7.43 (m, 2H), 4.02 (s,2H) ppm; 13C NMR (CDCl3, 100 MHz) δ148.09, 146.79,144.81, 143.92, 139.47, 128.87, 127.43, 125.43, 123.14, 121.34,120.49, 119.88, 36.96 ppm.
References:
Hosseinzadeh, Rahman;Nemati, Mohammad;Zadmard, Reza;Mohadjerani, Maryam [Beilstein Journal of Organic Chemistry,2016,vol. 12,p. 1749 - 1757]
3096-52-4
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607-57-8
177 suppliers
$16.00/5g
7149-70-4
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$9.00/1g
607-57-8
177 suppliers
$16.00/5g