2'-O,4'-C-Methyleneguanosine synthesis
- Product Name:2'-O,4'-C-Methyleneguanosine
- CAS Number:207131-16-6
- Molecular formula:C11H13N5O5
- Molecular Weight:295.26
709641-77-0
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207131-16-6
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Yield:207131-16-6 49%
Reaction Conditions:
Stage #1: (1R,3R,4R,7S)-3-(guanin-9-yl)-7-benzyloxy-1-benzoyloxymethyl-2,5-dioxabicyclo-[2.2.1]heptanewith methanesulfonic acid in dichloromethane at 0 - 20; for 4 h;
Stage #2: with Amberlyst A-26 (OH--form) in ethanol;dichloromethane; for 0.5 h;
References:
Rosenbohm, Christoph;Pedersen, Daniel Sejer;Frieden, Miriam;Jensen, Flemming R.;Arent, Susan;Larsen, Sine;Koch, Troels [Bioorganic and Medicinal Chemistry,2004,vol. 12,# 9,p. 2385 - 2396]
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1152762-57-6
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293751-16-3
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207131-16-6
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207131-16-6
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405290-35-9
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207131-16-6
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