2'-O-Methylguanosine synthesis
- Product Name:2'-O-Methylguanosine
- CAS Number:2140-71-8
- Molecular formula:C11H15N5O5
- Molecular Weight:297.27
280-57-9
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194034-59-8
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2140-71-8
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Yield:2140-71-8 1.25 g (65%)
Reaction Conditions:
in water;
Steps:
9 2'-O-Methyl Guanosine (9)
2'-O-Methyl Guanosine (9) A mixture of 5 (2.05 g, 6.5 mmol), 1,4-diazabicyclo[2.2.2]octane (1 equiv.) and water (30 mL) was heated to 90° C. for 45 minutes. Then the solution was cooled to ambient temperature, basified to pH 12 with 2M NaOH, and washed with methylene chloride (3*60 mL). The aqueous phase was acidified to pH 6 with 6M HCl and left at refrigerator overnight. Formed precipitate was filtered off. Mother liquor was evaporated to dryness, the residue was dissolved in water and applied to the short column with RP-18 silica gel. Solid phase was washed with water and remaining product was eluted with 5% aq methanol. Appropriate fractions were combined, evaporated to dryness and recrystallized from to provide 1.25 g (65%) of 2'-O-methyl guanosine 9. Analytical sample was recrystallized from water, m.p. The product was identical to authentic sample by HPLC, UV, 1 H-NMR-spectroscopy. 3',5'-di-O-Acetyl-2'-O-Methyl-6-Chloropurine Riboside (7)
References:
US5962675,1999,A
80791-87-3
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2140-71-8
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$20.19/250mg
![Guanosine, 2'-O-methyl-3',5'-O-[methylenebis[bis(1-methylethyl)silylene]]-](/CAS/20210305/GIF/572912-50-6.gif)
572912-50-6
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2140-71-8
251 suppliers
$20.19/250mg
194034-59-8
21 suppliers
$1066.00/1g
2140-71-8
251 suppliers
$20.19/250mg
194034-67-8
0 suppliers
inquiry
2140-71-8
251 suppliers
$20.19/250mg