2-Piperazineethanol,(2R)-(9CI) synthesis
- Product Name:2-Piperazineethanol,(2R)-(9CI)
- CAS Number:660862-46-4
- Molecular formula:C6H14N2O
- Molecular Weight:130.19
857334-79-3
13 suppliers
inquiry
660862-46-4
23 suppliers
$1078.00/1g
Yield: 100%
Reaction Conditions:
with hydrogen;20% Pd(OH)2 on carbon in methanol under 2585.81 Torr;
Steps:
c
A Parr bottle was charged with a solution of 2- ( (R)-4-benzyl-piperazin-2-yl)-ethanol (2.87 g, 13.03 mmol) in 50 mL of MeOH. 500 mg of Pearlman's catalyst was added and the mixture was placed under 50 psi of H2 and agitated on a Parr shaker. After 1 hr, a large initial uptake of H2 was observed. The vessel was repressurized to 50 psi and agitated overnight. The bottle was purged of H2 and removed from the Parr shaker. The reaction mixture was filtered through diatomaceous earth and the filter cake was washed with MeOH. The filtrate was concentrated in vacuo to give quantitative yield of product. 1H-NMR : 300MHz, CDC13 5 3.82 (m, 2H); 3.02-2. 69 (m, 6H); 2.6-2. 52 (m, 1H) ; 1.62 (m, 2H).
References:
ASTRAZENECA AB WO2005/61510, 2005, A1 Location in patent:Page/Page column 15
1485770-18-0
0 suppliers
inquiry
660862-46-4
23 suppliers
$1078.00/1g
857334-77-1
0 suppliers
inquiry
660862-46-4
23 suppliers
$1078.00/1g