ChemicalBook CAS DataBase List 2-tert-Butyl-4-chlorophenol

2-tert-Butyl-4-chlorophenol synthesis

4synthesis methods

Product Name:2-tert-Butyl-4-chlorophenol
CAS Number:13395-85-2
Molecular formula:C10H13ClO
Molecular Weight:184.66

106-48-9

75-65-0

13395-85-2

Step 1: Synthesis of 2-(tert-butyl)-4-chlorophenol (P19a) Concentrated hydrochloric acid was added to a mixture of 4-chlorophenol (50 g, 0.39 mol) and tert-butanol (57.6 g, 0.78 mol). Subsequently, sulfuric acid (40 mL) was added and the reaction mixture was stirred at room temperature for 48 hours. After completion of the reaction, the mixture was poured into ice water and extracted twice with ethyl acetate (EA). The organic layers were combined, washed sequentially with water (3 times) and brine, and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated and purified by column chromatography (eluent: petroleum ether/ethyl acetate = 40/1) to afford compound P19a (48.5 g, 68% yield) as a colorless solid.

106-48-9
499 suppliers
$10.00/5 g

75-65-0 Synthesis

75-65-0
795 suppliers
$10.00/10ml

13395-85-2
63 suppliers
$30.00/25mg

Yield: 71%

Reaction Conditions:

with sulfuric acid for 48 h;Inert atmosphere;

Steps:

1 Salicylaldehyde Synthesis.
The ligand precursor 3-ter -butyl-5-chlorosalicylaldehyde has been previously reported, and ^{FontWeight="Bold" FontSize="10"}H NMR assignments are included that match well with those in the literature. The yield represents average isolated yields. The precursor to the salicylaldehyde, 2-tert- butyl-4-chlorophenol, was synthesized according to literature procedure. 4-Chlorophenol (Combi-B locks, 8.00 g, 62.2 mmol) was dissolved in tert-butyl alcohol (Aldrich, 1 1.9 mL, 124 mmol), and 7.50 mL of concentrated H₂S0₄ was added dropwise over 5 minutes, turning the solution from a pale yellow to a light orange. The solution was stirred for 2 days, neutralized with Na₂C0₃ (aq), and then extracted into diethyl ether and dried over Na₂S0₄. The product was concentrated and purified by column chromatography (95:5, hex:EtOAc) resulting in a yellow oil (71% isolated yield). Using a modified Duff reaction, 2-/ert-butyl-4- chlorophenol was formylated as reported by Jacobsen et al. The product was purified by column chromatography (90: 10, hex:EtOAc) to yield a crystalline yellow solid (24% isolated yield). NMR spectrum in ppm (CDC1₃, 400 MHz): δ 1 1.72 (s, I H); 9.82 (s, IH); 7.46 (d, J = 2.6 Hz, IH); 7.38 (d, J = 2.6 Hz, IH); 1.41 (s, 12H).

References:

CORNELL UNIVERSITY;COATES, Geoffrey;WHITEHEAD, Julie WO2016/25675, 2016, A1 Location in patent:Paragraph 0100