N-{2-chloro-4-[(2-hydroxy-2-methylpropyl)amino]quinolin-3-yl}-2-ethoxyacetamide synthesis
- Product Name:N-{2-chloro-4-[(2-hydroxy-2-methylpropyl)amino]quinolin-3-yl}-2-ethoxyacetamide
- CAS Number:253120-65-9
- Molecular formula:C17H22ClN3O3
- Molecular Weight:351.83
![2-Propanol, 1-[(3-amino-2-chloro-4-quinolinyl)amino]-2-methyl-](/CAS/20180529/GIF/133860-78-3.gif)
133860-78-3
3 suppliers
inquiry
14077-58-8
82 suppliers
$27.57/250mgs:
253120-65-9
1 suppliers
inquiry
Yield:253120-65-9 50%
Reaction Conditions:
with triethylamine in dichloromethane; for 3 h;
Steps:
6 Preparation of compound 2-6
Preparation of compound 2-6 To a solution of 2-5 (5.7 g, 21.5 mmol) and TEA (4 g, 40 mmol) in DCM( 100 mL) was added compound 2-ethoxyacetyl chloride (3 g). The mixture was stirred for 3hrs, and then it was washed with sat. brine. The organic layer was concentrated and theresidue was purified by silica gel column chromatography (EA: PE=1 :2). The desiredproduct was obtained (3.7 g, 50%).
References:
WO2013/67597,2013,A1 Location in patent:Page/Page column 79
![1-[(2-chloro-3-nitro-4-quinolinyl)amino]-2-methyl-2-propanol](/CAS/20200331/GIF/133860-77-2.gif)
133860-77-2
0 suppliers
inquiry
253120-65-9
1 suppliers
inquiry
15151-57-2
84 suppliers
inquiry
253120-65-9
1 suppliers
inquiry
70254-44-3
30 suppliers
inquiry
253120-65-9
1 suppliers
inquiry
132521-66-5
103 suppliers
inquiry
253120-65-9
1 suppliers
inquiry