alpha-cyclopropyl-4-fluoro-alpha-methylbenzyl alcohol synthesis
2synthesis methods
- Product Name:alpha-cyclopropyl-4-fluoro-alpha-methylbenzyl alcohol
- CAS Number:2542-09-8
- Molecular formula:C11H13FO
- Molecular Weight:180.22
Yield:2542-09-8 64%
Reaction Conditions:
Stage #1: 1-Bromo-4-fluorobenzenewith iodine;magnesium in tetrahydrofuran at 20; for 2 h;Inert atmosphere;
Stage #2: Cyclopropyl methyl ketone in tetrahydrofuran at 0 - 20; for 1 h;Inert atmosphere;Grignard reaction;
Stage #3: with water in tetrahydrofuran;Inert atmosphere;Grignard reaction;
References:
Singh, Fateh V.;Wirth, Thomas [Organic Letters,2011,vol. 13,# 24,p. 6504 - 6507] Location in patent:supporting information; experimental part
