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ChemicalBook CAS DataBase List 3-(2-Methoxy-phenoxy)-propionic acid
20370-80-3

3-(2-Methoxy-phenoxy)-propionic acid synthesis

5synthesis methods
-

Yield:20370-80-3 90%

Reaction Conditions:

with hydrogenchloride in water at 80 - 90;

Steps:

General experimental procedure for the synthesis of 3-aryloxypropanoic acids (3a-3o)

General procedure: Mixture of 3-aryloxypropane nitrile (2a-2o) (2 mmol) and conc. HCl (1-2 mL) is heated at 80-90 °C for about 1- 2 h (after monitoring the reaction completion by TLC). Cooled the reaction mass and added ice water to obtain solid 3-aryloxypropanoic acid (3a-3o) as solids which is filtered and dried to be taken up for the subsequent step.

References:

Begum, Ayisha F.;Balasubramanian, Kalpattu K.;Shanmugasundaram, Bhagavathy [Tetrahedron Letters,2021,vol. 82,art. no. 153372] Location in patent:supporting information

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