3,4,5-TRIMETHOXYBENZAMIDE synthesis
- Product Name:3,4,5-TRIMETHOXYBENZAMIDE
- CAS Number:3086-62-2
- Molecular formula:C10H13NO4
- Molecular Weight:211.21
18638-99-8
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$16.00/500 mg
3086-62-2
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$42.29/25g
Yield: 90%
Reaction Conditions:
with tert.-butylhydroperoxide;caesium carbonate in water;acetonitrile for 4 h;Reflux;
Steps:
General procedure for the synthesis of substituted benzamide (4a-4j) as exemplified for the synthesis of 3b.
General procedure: To a solution of 4-methoxybenzyl amine (1.0 mmol) and cesium carbonate (1.0 mmol) in 3 mL of CH3CN was added a solution of 70% aqueous TBHP (3.0 mmol) and the mixture was refluxed for 4 h. The mixture was then dried to vacuum and extracted three times with ethyl acetate followed by washing with brine,and dried over anhydrous Na2SO4. Evaporation of the solvent under vacuum afforded the crude product, which was furthur purified by column chromatography using hexane/ethyl acetate mixture and then analyzed by spectroscopy.
References:
Gupta, Sampa;Ansari, Alisha;Sashidhara, Koneni V. [Tetrahedron Letters,2019,vol. 60,# 39,art. no. 151076] Location in patent:supporting information
86-81-7
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$16.26/10gm:
3086-62-2
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$42.29/25g
39201-89-3
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$15.00/5mg
3086-62-2
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$42.29/25g
4521-61-3
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$29.00/5g
3086-62-2
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1885-35-4
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$18.00/1g
3086-62-2
138 suppliers
$42.29/25g