3,4-DICHLOROPHENYLACETYLENE synthesis
- Product Name:3,4-DICHLOROPHENYLACETYLENE
- CAS Number:556112-20-0
- Molecular formula:C8H4Cl2
- Molecular Weight:171.02
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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556112-20-0
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Yield: 94%
Reaction Conditions:
with methanol;potassium hydroxide in dichloromethane at 20; for 1 h;
Steps:
1
Synthesis of Compound 440. A mixture of 439 (2.54 g, 10.4 mmol) and potassium hydroxide (1.17 g, 20.9 mmol) in methanol (20 mL) and methylene chloride (10 mL) was stirred at room temperature for 1 h. After this time, the reaction mixture was poured into water (30 mL) and extracted with methylene chloride (3 x 30 mL). The combined organic extracts were dried over magnesium sulfate, filtered and concentrated to afford 440 (1.68 g, 94%) which was used as an appropriate alkyne in Example 9 without further purification.
References:
RESOLVYX PHARMACEUTICALS, INC.;GJORSTRUP, Per WO2010/91226, 2010, A1 Location in patent:Page/Page column 123-124
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