3',5'-DICHLORO-4'-HYDROXYACETOPHENONE synthesis
- Product Name:3',5'-DICHLORO-4'-HYDROXYACETOPHENONE
- CAS Number:17044-70-1
- Molecular formula:C8H6Cl2O2
- Molecular Weight:205.04
3336-41-2
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17044-70-1
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$80.00/2 g
Yield:-
Steps:
Multi-step reaction with 3 steps
1: 1.) K2CO3, 2.) 2.5 N NaOH / 1.) DMF, 55 deg C, 1 8 h, 2.) methanol, reflux, 4 h
2: 1.) thionyl chloride, 2.) triethylamine / 1.) DMF, reflux, 4 h, 2.) RT, overnight
3: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 3 h / Ambient temperature
References:
Huang, Horng-Chih;Li, James J.;Garland, Danny J.;Chamberlain, Timothy S.;Reinhard, Emily J.;Manning, Robert E.;Seibert, Karen;Koboldt, Carol M.;Gregory, Susan A.;Anderson, Gary D.;Veenhuizen, Amy W.;Zhang, Yan;Perkins, William E.;Burton, Earl G.;Cogburn, J. Nita;Isakson, Peter C.;Reitz, David B. [Journal of Medicinal Chemistry,1996,vol. 39,# 1,p. 253 - 266]
28165-71-1
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17044-70-1
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99-93-4
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$5.00/25g
17044-70-1
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87-65-0
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17044-70-1
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37908-97-7
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$11.00/250mg
17044-70-1
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