3-CHLORO-2-FLUOROPHENOL synthesis
- Product Name:3-CHLORO-2-FLUOROPHENOL
- CAS Number:2613-22-1
- Molecular formula:C6H4ClFO
- Molecular Weight:146.55
261762-56-5
106 suppliers
$9.00/1g
2613-22-1
136 suppliers
$6.00/1g
Yield:2613-22-1 60%
Reaction Conditions:
with hydrogen bromide at 100 - 110; for 7 h;
Steps:
1.4; 2-15
(4) Put 112.4g of 2-fluoro-3-chloroanisole obtained in step (3) and 600g of 50% hydrobromic acid into a 2L four-necked flask, heat it up to 100-110°C, reflux and keep incubating for 7 hours, and sample and control it. HPLC: 2-fluoro-3-chloroanisole≤5%, 2-fluoro-3-chlorophenol≥95%, stop the reaction. Cool down to 20-30°C, add 300g of dichloromethane*3 and extract three times, then strip the oil layer with 200g of 20% liquid caustic soda, cool the water layer to 0-10°C, slowly add hydrochloric acid dropwise to adjust pH=1-2, a large amount of precipitation White crystals are filtered, washed with a small amount of water, and dried under vacuum at 20-30°C for 24 hours to obtain 87.9 g of 2-fluoro-3-chlorophenol. HPLC: ≥98%, total yield 60%
References:
Zhejiang Yongtai Technology Co., Ltd.;Shao Hongming;Zhang Xing;Yu Bo;Hu Jie;Li Hongkui CN112142567, 2020, A Location in patent:Paragraph 0041; 0046-0047; 0049-0050; 0052-0053; 0055-0056
2106-04-9
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$6.00/10g
2613-22-1
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$6.00/1g
3209-22-1
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$10.00/1g
2613-22-1
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$6.00/1g
2106-49-2
191 suppliers
$5.00/5g
2613-22-1
136 suppliers
$6.00/1g