3-CHLORO-4-FLUOROPHENYL ISOTHIOCYANATE synthesis
- Product Name:3-CHLORO-4-FLUOROPHENYL ISOTHIOCYANATE
- CAS Number:137724-66-4
- Molecular formula:C7H3ClFNS
- Molecular Weight:187.62
367-21-5
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6160-65-2
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137724-66-4
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Yield:-
Reaction Conditions:
in tetrahydrofuran at 45;
Steps:
General procedure for the preparation of intermediates 2
General procedure: Add compound 1 (1 mmol) to a solution of di(1H-imidzazol-1-yl)methanethione (196 mg, 1.1 mmol) in 5 ml THF. The resulting reaction mixture was heated at 45 °C for 0.5-1.5 h. The reaction was then cooled to room temperature to give a mixture containing intermediate 2. The specific mass of compound 1 required for the reaction was: 3-chloro-4-fluoroaniline (146 mg, 1 mmol), thiazol-2-amine (100 mg, 1 mmol), 4-chloroaniline (128 mg, 1 mmol), 4-fluoroaniline (111 mg, 1 mmol), 1,3-dimethyl-1H-pyrazol-5-amine (111 mg, 1 mmol), 3-chloroaniline (128 mg, 1 mmol), 3,4-dichloroaniline (162 mg, 1 mmol), 4,4-dimethylcyclohexan-1-amine (127 mg, 1 mmol), 4-bromoaniline (172 mg, 1 mmol), naphthalen-1-amine (143 mg, 1 mmol), 4-(trifluoromethyl)aniline (161 mg, 1 mmol), [1,1′-biphenyl]-4-amine (169 mg, 1 mmol), 4-isopropylaniline (135 mg, 1 mmol), 3-(oxazol-5-yl)aniline (160 mg, 1 mmol), 1-methyl-3-phenyl-1H-pyrazol-5-amine (173 mg, 1 mmol).
References:
Xiang, Jiawei;Tao, Lei;Zhou, Yue;Tan, Yuping;Li, Zicheng;Zhao, Yinglan;Sun, Qingxiang;Luo, Youfu [Chemical Papers,2020,vol. 74,# 11,p. 3873 - 3886]
367-21-5
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463-71-8
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137724-66-4
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$45.00/1 g
75-15-0
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367-21-5
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$5.00/25g
137724-66-4
99 suppliers
$45.00/1 g
367-21-5
532 suppliers
$5.00/25g
137724-66-4
99 suppliers
$45.00/1 g
367-21-5
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16420-13-6
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137724-66-4
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$45.00/1 g