3-CHLOROPYRIDINE-2-ACETIC ACID synthesis
- Product Name:3-CHLOROPYRIDINE-2-ACETIC ACID
- CAS Number:885167-73-7
- Molecular formula:C7H6ClNO2
- Molecular Weight:171.58
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Yield: 82%
Reaction Conditions:
with sodium hydroxide in tetrahydrofuran at 20; for 1 h;
Steps:
120.3 Step 3: 2-(3-chloropyridin-2-yl)acetic acid
To a solution of ethyl 2-(3-chloropyridin-2-yl)acetate (7.8 g, 39.1 mmol) in THF (130 ml) was added 1.0 M sodium hydroxide solution (78 ml, 78 mmol). Theresulting mixture was stirred at rt for 1 h. LCMS showed the completion of reaction. pH of the reaction mixture was adjusted with 1 N HC1 to pH 3. The organic solvent was removed in vacuo. The resulting precipitate was collected via filtration, washed with water and ethyl acetate and dried under vacuum to give the product as white solid (5.5 g, 82%). LC-MS calculated for C7H7C1NO2 (M+H): mlz = 172.0; found172.0.
References:
INCYTE CORPORATION;HOANG, Gia;WANG, Xiaozhao;CARLSEN, Peter Niels;GAN, Pei;LI, Yong;QI, Chao;WU, Liangxing;YAO, Wenqing;YU, Zhiyong;ZHU, Wenyu WO2020/10197, 2020, A1 Location in patent:Page/Page column 255-256
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885167-73-7
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