3-FORMYL RIFAMYCIN SV synthesis
- Product Name:3-FORMYL RIFAMYCIN SV
- CAS Number:13292-22-3
- Molecular formula:C38H47NO13
- Molecular Weight:725.78
13292-46-1
609 suppliers
$15.00/1G
13292-22-3
156 suppliers
$39.00/500mg
Yield: 95%
Reaction Conditions:
with hydrogenchloride;water at 55; for 8 h;Temperature;
Steps:
1-2 Example 2
100g of rifampicin to be purified was added to 1200mL of water, 50mL of hydrochloric acid (35% -37%, g: mL) was added, heated to 55 for 8h, cooled to 10 , extracted with 1000mL of ethyl acetate, and the organic layer was saturated The solution was washed with an aqueous solution of sodium bicarbonate, and the organic layer was separated. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 83.78 g of Compound II (3-formylrifamycin SV). The yield was 95.0%.
References:
Chengdu Jin Hua Pharmaceutical Co., Ltd.;Yan Dong;Jiang Min;Guo Min;Wang Qing;Zhou Hongyun;Zhang Fan;Huang Hui;Sun Haili;Li Lin;Fu Pan CN111018887, 2020, A Location in patent:Paragraph 0042-0045
13292-46-1
609 suppliers
$15.00/1G
13292-22-3
156 suppliers
$39.00/500mg