3-hydroxy-3-phenyl-butan-2-one synthesis
- Product Name:3-hydroxy-3-phenyl-butan-2-one
- CAS Number:3155-01-9
- Molecular formula:C10H12O2
- Molecular Weight:164.2
127-66-2
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Yield: 91 %Spectr. ， 89 %Spectr.
Reaction Conditions:
with silver nitrate;1-ethyl-3-methylimidazolium acetate at 60; under 750.075 Torr; for 36 h;Schlenk technique;
Steps:
2.3. General procedures for the synthesis of 2-oxazolidinones and ahydroxylketones
General procedure: The synthesis of 2-oxazolidinones and a-hydroxyl ketones wasperformed in a 15 mL Schlenk tube. AgNO3 (0.0125 mmol,0.25 mol%), [C2C1im][OAc] (6 mmol), 2-aminoethanols (5 mmol)and propargyl alcohols (7.5 mmol) were first added. Then the systemwas purged with CO2 three times and the mixture was stirredat 60 °C under 0.1 MPa of CO2 for 12 h. Afterwards, the mixture wasextracted with diethyl ether (5 x 10 mL) and the upper layers werecollected and concentrated under vacuum to give the raw products,which were further purified by column chromatography on silicagel using petroleum ether/ethyl acetate (v/v, 5:1-1:1) as the eluent.When the recyclability of the catalytic system was investigated, thelower layer was recycled and reused directly for the next roundafter drying under vacuum at 60 °C for 4 h.
References:
Bu, Chao;Chaemchuen, Somboon;Chen, Cheng;Du, Minchen;Gong, Yanyan;Hu, Jia;Verpoort, Francis;Yuan, Ye;Zhang, Yongxing [Journal of Catalysis,2021,vol. 393,p. 70 - 82]
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57-55-6
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108-32-7
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