3-Hydroxytetrahydrofuran synthesis
- Product Name:3-Hydroxytetrahydrofuran
- CAS Number:453-20-3
- Molecular formula:C4H8O2
- Molecular Weight:88.11
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453-20-3
The general procedure for the synthesis of 3-hydroxytetrahydrofuran from 1,2,4-butanetriol is as follows: 1,2,4-butanetriol is mixed with an equal volume of dioxane as a solvent in a batch reactor and a strongly acidic ion-exchange resin containing sulfonic acid groups (Amberlyst 15, in the H+ form) is added as a catalyst. The reaction was carried out at 100 °C for 20 h at atmospheric pressure. Upon completion of the reaction, the yield of 3-hydroxytetrahydrofuran was 96 mol%.
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Yield:453-20-3 96%
Reaction Conditions:
strong acid ion exchange resin (Amberlyst 15, H+ form) in 1,4-dioxane at 100; under 760.051 Torr; for 20 h;Product distribution / selectivity;
Steps:
1
Example 1; Instead of PEG-400 and the para-toluenesulfonic acid catalyst used in ComparativeExample 1, dioxane and a strong acid ion exchange resin (Amberlyst 15, H+ form) containing a sulfonic acid group were used in equal amounts. Then, the reaction was conducted using a batch type reactor under conditions of atmospheric pressure and 1000C for 20 hours. The reaction yield was 96 mol%.
References:
WO2007/81065,2007,A1 Location in patent:Page/Page column 6
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