3'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE synthesis
- Product Name:3'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE
- CAS Number:30724-22-2
- Molecular formula:C9H7F3O2
- Molecular Weight:204.15
181820-18-8
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Yield: 68%
Reaction Conditions:
with tris-(dibenzylideneacetone)dipalladium(0);copper(I) thiophene-2-carboxylate;trifuran-2-yl-phosphane in tetrahydrofuran at 30; for 18 h;Sealed tube;Inert atmosphere;
Steps:
General Procedure for Palladium-Catalyzed Trifluoroacylation of (Hetero)arylboronic Acid with Fluorothioacetates
General procedure: To a 25 mL sealed tube was added substrates 1 (0.2 mmol, 1 equiv), Pd2dba3·CHCl3 (2.3 mg, 1 mol%), CuTC (57 mg, 0.3 mmol), TFP (1.4 mg, 3 mol%), 2d (74.4 mg, 0.4 mmol) and THF (2 mL). The reaction vessel was purged with nitrogen three times. Then the reaction mixture was stirred at 30 °C for 18 h. Upon completion, EtOAc was added to dilute the mixture and washed with NH3·H2O and saturated NaCl (aq). The organic fraction was dried over anhydrous Na2SO4, evaporated and the residue purified by a silica gel packed flash chromatography column, using ethyl acetate/hexane as the eluent.
References:
Ban, Shu-Rong;Cao, Ya-Fang;Dai, Hui-Xiong;Wang, Xing;Xu, Hui;Yi, Xing [Tetrahedron Letters,2020] Location in patent:supporting information
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