3-METHOXY-2-NAPHTHOIC ACID synthesis
- Product Name:3-METHOXY-2-NAPHTHOIC ACID
- CAS Number:883-62-5
- Molecular formula:C12H10O3
- Molecular Weight:202.21
Yield: 89%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 90; for 10 h;Cooling with ice;
Steps:
36.a Preparation of 3-methoxy-2-naphthoic acid
Reaction flask was added 9.0 g (48. 0mmol) 3- hydroxy-2-naphthoic acid, 16.56 g (120mmol) anhydrous Of potassium carbonate and 30 ml of DMF dried, stirred in an ice bath to cool, 15 g (105mml) of methyl iodide was slowly dropwise added to the reaction Shall flask, the reaction solution was heated to 90 ° C, for 10 hours. The reaction mixture was poured into water and extracted with ethyl acetate, washed with saturated Sodium chloride solution and the organic layer was washed three times, dried over anhydrous sodium sulfate, and concentrated. The concentrate was dissolved in methanol 45 ml, was added slowly Into 30 ml 6N sodium hydroxide solution, stirred at room temperature for 5 hours. Extracted three times, the aqueous layer (ice) with ethyl acetate concentrated hydrochloric Acidified to give a yellow solid which was recrystallized from ethanol to give 8.6 g of yellow crystals, yield 89%,
References:
INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES;YANG, GUANGZHONG;QIN, FANG;ZHANG, JIANJUN;WANG, YAFANG;WEN, HUI;JI, CHENGXUE CN101602750, 2016, B Location in patent:Paragraph 0267; 0268
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