3-methoxy-4-nitrophenol synthesis
- Product Name:3-methoxy-4-nitrophenol
- CAS Number:16292-95-8
- Molecular formula:C7H7NO4
- Molecular Weight:169.13
448-19-1
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$5.00/1g
16292-95-8
105 suppliers
$11.00/250mg
Yield: 95%
Reaction Conditions:
Stage #1:4-fluoro-2-methoxy-1-nitrobenzene with water;sodium hydroxide in dimethyl sulfoxide at 80; for 20 h;
Stage #2: with hydrogenchloride in water;dimethyl sulfoxide; pH=5 at 20;
Steps:
132.A
To a solution of 4-fluoro-2-methoxy-1-nitrobenzene (Combi-blocks, 3.4 g, 19.9 mmol) in DMSO (40 mL) was added an aqueous solution (1N) of NaOH (40 mL, 40 mmol). The reaction mixture was heated at 80° C. for 20 h. The mixture was cooled to room temperature, and the "pH” of the solution was adjusted to 5 by aqueous HCl solution. The mixture was extracted with ethyl acetate three times. The combined organic extract was washed with water, brine, dried over MgSO4, and concentrated to give 3-methoxy-4-nitrophenol as a light yellow solid (3.2 g, 95%).
References:
Bartkovitz, David Joseph;Chu, Xin-Jie;Ding, Qingjie;Graves, Bradford James;Jiang, Nan;Zhang, Jing;Zhang, Zhuming US2011/130398, 2011, A1 Location in patent:Page/Page column 60
150-19-6
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$6.00/5g
16292-95-8
105 suppliers
$11.00/250mg
394-41-2
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$16.00/1g
124-41-4
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16292-95-8
105 suppliers
$11.00/250mg
67-56-1
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394-41-2
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$16.00/1g
16292-95-8
105 suppliers
$11.00/250mg
150-19-6
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3114-61-2
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$69.00/100mg
16292-95-8
105 suppliers
$11.00/250mg
704-14-3
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$7.00/1g