3-methylphenethyl bromide synthesis
- Product Name:3-methylphenethyl bromide
- CAS Number:16799-08-9
- Molecular formula:C9H11Br
- Molecular Weight:199.09
558-13-4
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Yield: 7.0 g (95%)
Reaction Conditions:
with triphenylphosphine in dichloromethane
Steps:
52.1.2.A Hydrocinnamoyl-[N-(3-methylphenethyl)-Gly]-boroLys--OH hydrochloride salt
Part A. Preparation of 3-methylphenethyl bromide. To a solution of 3-methylphenethyl alcohol (5.0 g, 36.7 mmol) in methylene chloride at 0° C. was added triphenylphosphine (10.6 g, 40.4 mmol) and carbon tetrabromide (13.4 g, 40.4 mmol). The mixture was allowed to stir with warming to 25° C. for 16 h. The solvent was removed in vacuo and the residue was taken up in ether and filtered through a pad of silica gel. The solvent was removed in vacuo to afford 7.0 g (95%) of the title bromide.
References:
DuPont Pharmaceuticals Company US6060462, 2000, A
1875-89-4
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16799-08-9
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28987-79-3
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16799-08-9
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621-36-3
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40061-55-0
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16799-08-9
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