3'-NITROACETANILIDE synthesis
- Product Name:3'-NITROACETANILIDE
- CAS Number:122-28-1
- Molecular formula:C8H8N2O3
- Molecular Weight:180.16
Yield: 90%
Reaction Conditions:
with magnesia in neat (no solvent) at 70; for 0.5 h;Green chemistry;chemoselective reaction;
Steps:
General procedure for the synthesis of amides
General procedure: In an oven dried round bottomed flask (50 mL) nano-MgO (5.0 mol%) were added and then alky/aryl amines (5.0 mmol) and aromatic/aliphatic acid (5.0 mmol) was added. After that it was allowed to stir on a pre heated oil bath at 70 °C under aerobic condition till the required time (the progress of the reaction was judged by TLC). After the completion, the reaction mixture was brought to room temperature and ethyl acetate (3 × 10 mL) was added to it and then centrifuged at 3500 rpm to recover the nano catalyst. Having done this, the reaction mixture was washed with water and brine, dried over anhydrous Na2SO4, concentrated in a rotary evaporator and finally the crude product was charged to column chromatography (ethylacetate:hexane (3:7) as an eluent) for purification and wherever necessary the products were recrystallized from hot ethanol.
References:
Das, Vijay Kumar;Devi, Rashmi Rekha;Thakur, Ashim Jyoti [Applied Catalysis A: General,2013,vol. 456,p. 118 - 125]
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