3-(oxiran-2-yl)benzonitrile synthesis
- Product Name:3-(oxiran-2-yl)benzonitrile
- CAS Number:13906-62-2
- Molecular formula:C9H7NO
- Molecular Weight:145.16
2181-42-2
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Yield:13906-62-2 55%
Reaction Conditions:
with potassium hydroxide in water;acetonitrile at 60; for 15 h;
Steps:
A34.a
A solution of trimethylsulfonium iodide (4.49 g, 22.0 mmol) in acetonitrile (40 ml), KOH (2.64 g, 40.0 mmol) and H2O (0.100 ml) was added at room temperature and stirred at 60 °C for 15 hours. The reaction was quenched with brine, extracted with diethyl ether (100 ml x 2), washed with brine, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by column chromatography on silica (ethyl acetate/hexane, 25/75) to give 3-(oxiran-2-yl)benzonitrile (1.63 g, 55 %, colorless oil).
References:
WO2008/8398,2008,A2 Location in patent:Page/Page column 367
50916-55-7
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5338-96-5
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24964-64-5
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