(3-(Phenylethynyl)phenyl)methanol synthesis
- Product Name:(3-(Phenylethynyl)phenyl)methanol
- CAS Number:123926-88-5
- Molecular formula:C15H12O
- Molecular Weight:208.26
Yield:123926-88-5 98%
Reaction Conditions:
with bis-triphenylphosphine-palladium(II) chloride;cholin hydroxide at 40; for 2 h;Green chemistry;Sonogashira Cross-Coupling;
Steps:
General procedure for coupling reaction
General procedure: To a 25 mL round-bottom flask equipped with a magnetic bar, phenylacetylene (4.5 mmol), aryl halide (3.0 mmol), Pd(PPh3)2Cl2 ( 2.0 mol%) and ChOH (4.0 mL) were added. Then, the mixture was stirred at 40°C. After being stirred, the reaction mixture was filtered. Then, the filtrate was acidified with 3M HCl aqueous solution, and the aqueous layer was extracted with diethyl ether (3 X 10 mL). The combined organic layers were washed with brine, dried with anhydrous Na2SO4, and evaporated under reduced pressure. The crude mixture was purified by column chromatography on silica gel (hexanes/ ethyl acetate).
References:
Jung, Da-Young;Park, Soo Youl;Kim, Seung-Hoi [Bulletin of the Korean Chemical Society,2022,vol. 43,# 1,p. 110 - 116] Location in patent:supporting information
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![Benzoic acid, 3-[(1E)-2-phenylethenyl]-](/CAS/20210305/GIF/135008-92-3.gif)
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