3-(PROPYLAMINO)PROPIONITRILE synthesis
- Product Name:3-(PROPYLAMINO)PROPIONITRILE
- CAS Number:7249-87-8
- Molecular formula:C6H12N2
- Molecular Weight:112.17
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Yield:7249-87-8 95%
Reaction Conditions:
with aluminum oxide in neat (no solvent) at -20; for 3 h;Green chemistry;Michael Addition;
Steps:
3.2. Procedure for Preparation of Mono-Adducts
General procedure: The amine (7.5 mmol) and the Michael acceptor (5 mmol) in a molar ratio of 1.5:1 were refluxedwith stirring in the presence of acidic alumina (1 g, 200 mol%). Heating was performed using an oilbath and the reaction was followed by TLC and GC until completion. The reaction was then allowedto cool down to room temperature and filtered through a filter paper. The catalyst was rinsed withethyl acetate/hexane and then concentrated by rotary evaporation. The crude reaction mixture waspurified using a silica-filled chromatographic column using hexane/ethyl acetate as eluents. Usually,for aliphatic amines, the mono-adduct was eluted using 7:3, 6:4 or 5:5 hexane/ethyl acetate whilstfor aromatic ones the solvent mixture used was 8:2 hexane/ethyl acetate. The yields of the purifiedproducts were recorded and then IR and NMR spectroscopy and MS spectrometry were performed.
References:
Bosica, Giovanna;Abdilla, Roderick [Molecules,2016,vol. 21,# 6,art. no. 815]
107-10-8
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$10.00/20mg
107-13-1
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$17.00/25ML
1555-59-5
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7249-87-8
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