一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 3(R)-HYDROXYMETHYLMORPHOLINE
211053-49-5

3(R)-HYDROXYMETHYLMORPHOLINE synthesis

2synthesis methods
(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE

101376-26-5

3(R)-HYDROXYMETHYLMORPHOLINE

211053-49-5

General procedure for the synthesis of (R)-3-hydroxymethylmorpholine from (R)-(4-benzyl-3-morpholinyl)-methanol: (a) Preparation of (3R)-morpholin-3-ylmethanol: [(3R)-4-benzylmorpholin-3-yl]methanol (cf. J. Med. Chem.; 29; 1986; 1288-1290; 1.1 g, 5.4 mmol) was dissolved in ethanol (25 mL), palladium hydroxide (20% loaded on activated carbon, 0.7 g) and acetic acid (0.5 mL). The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere (1.2 bar). After completion of the reaction, the catalyst was removed by filtration and the solvent was removed by evaporation under reduced pressure. The residue except 200 mg was dissolved in ether (1 mL) and tetrahydrofuran (10 mL). The solution was purified by passing it through a strong cation exchange column (Isolute SCX-2, 10 g). The column was first washed with tetrahydrofuran, followed by elution of the target product with ammonia-saturated methanol. The solvent was removed by evaporation under reduced pressure to give 0.3625 g (57% yield) of (3R)-morpholin-3-ylmethanol as an oil.1H NMR (500 MHz, CD3OD): δ 2.9 (m, 3H), 3.3 (t, 1H), 3.5 (m, 3H), 3.7-3.9 (m, 2H).

-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: dimethylsulfide borane complex; triethylamine / tetrahydrofuran / 5 h / 0 - 65 °C
2: hydrogen; palladium 10% on activated carbon / methanol / 48 h / 2100.21 Torr

References:

Borsari, Chiara;Rageot, Denise;Dall'Asen, Alix;Bohnacker, Thomas;Melone, Anna;Sele, Alexander M.;Jackson, Eileen;Langlois, Jean-Baptiste;Beaufils, Florent;Hebeisen, Paul;Fabbro, Doriano;Hillmann, Petra;Wymann, Matthias P. [Journal of Medicinal Chemistry,2019,vol. 62,# 18,p. 8609 - 8630]

3(R)-HYDROXYMETHYLMORPHOLINE Related Search:

土默特右旗| 宁都县| 广河县| 山东| 通江县| 西贡区| 客服| 美姑县| 福安市| 定襄县| 宣威市| 金川县| 诸城市| 平和县| 扎鲁特旗| 嘉荫县| 洛阳市| 婺源县| 刚察县| 天长市| 贵阳市| 于田县| 云梦县| 德安县| 泉州市| 鲁山县| 南康市| 赤峰市| 珲春市| 曲松县| 兴业县| 兴义市| 富宁县| 五家渠市| 布尔津县| 晋中市| 白玉县| 尼勒克县| 友谊县| 额敏县| 莱州市|