3-(Trifluoromethyl)benzaldehyde synthesis
- Product Name:3-(Trifluoromethyl)benzaldehyde
- CAS Number:454-89-7
- Molecular formula:C8H5F3O
- Molecular Weight:174.12
349-75-7
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454-89-7
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Yield:454-89-7 98%
Reaction Conditions:
with sodium hypochlorite solution;2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;potassium carbonate;isocyanuric acid in ethyl acetate; pH=> 12 at 0 - 10; for 5 h;
Steps:
General Procedure for the oxidation of alcohols employing nitroxyl radical / imide / NaOCl in the presence of K2CO3.
General procedure: To a mixture of the alcohol (3.839 mmol), K2CO3 (2.0 equiv, 7.678 mmol) and cyanuric acid (0.1 equiv, 0.384 mmol) in 20 mL of ethyl acetate were added TEMPO or AZADO (3 mol%, 0.115 mmol) and 12% NaOCl (1.2 equiv, 4.607 mmol, Wako Pure Chemical Industries, Ltd.) at 0-10°C. The mixture was then stirred to complete. The reaction mixture was extracted with ethyl acetate. The organic layer was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to afford the corresponding product.
References:
Fukuda, Naohiro;Izumi, Minoru;Ikemoto, Tomomi [Tetrahedron Letters,2015,vol. 56,# 25,p. 3905 - 3908] Location in patent:supporting information
201230-82-2
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401-81-0
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454-89-7
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368-77-4
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454-89-7
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368-83-2
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454-89-7
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