5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile synthesis
- Product Name:5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
- CAS Number:330792-70-6
- Molecular formula:C16H12N4O
- Molecular Weight:276.29
![Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-](/CAS/20150408/GIF/330792-69-3.gif)
330792-69-3
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Yield:330792-70-6 99%
Reaction Conditions:
with hydrazine hydrate in ethanol at 20 - 90; for 4 h;Reflux;
Steps:
1.F Step F:
5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
Step F:
5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
To 50 mL of EtOH at room temperature was added 2-(methoxy(4-phenoxyphenyl) methylene)malononitrile (1 g, 1.0 eq) followed by slow addition of hydrazine hydrate (0.5 g, 85%, 2.0 eq).
After completion of addition, the reaction mixture was heated to 90 °C and refluxed for 4 hours.
After completion of the reaction, the mixture was cooled to room temperature, and the solvent was removed with rotate evaporation.
Water (50 mL) was added and the mixture was stirred at room temperature for 5 minutes.
The white solid thus precipitated was collected and dried as the product (1.0 g, 99%).
1H NMR (400 MHz, DMSO) δ 7.78-7.81 (m, 2H), 7.40-7.44 (m, 2H), 7.16-7.20 (m, 1H), 7.06-7.11 (m, 4H), 6.26 (brs, 2H).
References:
EP3141546,2017,A1 Location in patent:Paragraph 0133; 0134; 0135
1623-95-6
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$215.61/1gm:
109-77-3
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$10.00/5g
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![Propanedinitrile, 2-[amino(4-phenoxyphenyl)methylene]-](/CAS/20210305/GIF/1055710-57-0.gif)
1055710-57-0
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330792-70-6
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2215-77-2
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$8.00/5g
330792-70-6
231 suppliers
inquiry
1623-95-6
54 suppliers
$215.61/1gm:
330792-70-6
231 suppliers
inquiry