3-[2-(diethylamino)ethyl]-2-(3-fluorophenyl)-2,3-dihydroquinazolin-4(1H)-one synthesis
- Product Name:3-[2-(diethylamino)ethyl]-2-(3-fluorophenyl)-2,3-dihydroquinazolin-4(1H)-one
- CAS Number:335206-51-4
- Molecular formula:C20H24FN3O
- Molecular Weight:341.42
![2-amino-N-[2-(diethylamino)ethyl]benzamide](/CAS/20200119/GIF/49667-85-8.gif)
Yield:335206-51-4 85%
Reaction Conditions:
with acetic acid in 5,5-dimethyl-1,3-cyclohexadiene;Reflux;
Steps:
Synthesis of quinazolinones (general procedure).
General procedure: To a solution of amino amide (0.005 mol) in a xylene-acetic acid (1 : 1) mix-ture (10 mL), 0.005 mol of the corresponding aldehyde (0.01 mol for the synthesis of compound 22) was added and the mixture was re uxed for 3-5 h (TLC control by aldehyde). After keeping under these conditions, the solvent was removed in vacuo, 2% hydrochloric acid was added to the residue, and the precipitate that formed was ltered off . The lter precipitate was washed with 5% soda solution and water and, if necessary, recrystallized from aqueous ethanol. The yields and physicochemical characteristics of 2-aryl quinazolinones 11a-y, 12a-l, 13a,b, 16, 18a,b, and 22a-f are given in Tables 2 and 3.
References:
Khachatryan;Belus;Misyurin;Baryshnikova;Kolotaev;Matevosyan [Russian Chemical Bulletin,2017,vol. 66,# 6,p. 1044 - 1058][Izv. Akad. Nauk, Ser. Khim.,2017,# 6,p. 1044 - 1058,15]
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