1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]TETRAHYDRO-4(1H)-PYRIDINONE synthesis
- Product Name:1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]TETRAHYDRO-4(1H)-PYRIDINONE
- CAS Number:339029-35-5
- Molecular formula:C11H10ClF3N2O
- Molecular Weight:278.66
41979-39-9
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$15.00/10mg
69045-84-7
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$10.00/5g
339029-35-5
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$98.00/500mg
Yield:339029-35-5 89%
Reaction Conditions:
in N,N-dimethyl-formamide at 70;
Steps:
3
Scheme 3IV l-(3-Chloro-5-(trifluoromethyl) pyrid-2-yI)-4-piperidone (IV).A solution of 2,3-dichloro-5-(trifluoromethyl)pyridine (32 mmol) and 4- piperidone hydrochloride monohydrate (32 mmol) in DMF (60 ml) was stirred at 700C overnight. After cooling, it was mixed with saturated NH4Cl solution and extracted with ethyl ether. The organic phase was dried with MgSO4 and the solvent was removed by rotavapor, obtaining crude product (IV) in 89% yield.
References:
WO2007/62175,2007,A2 Location in patent:Page/Page column 26