一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate
342417-02-1

Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate synthesis

11synthesis methods
342417-01-0 Synthesis
3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

342417-01-0
164 suppliers
$5.00/100mg

Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate

342417-02-1
18 suppliers
inquiry

-

Yield:342417-02-1 100%

Reaction Conditions:

Stage #1: sodium methylatewith N-Bromosuccinimide in methanol;dichloromethane at -5; for 16 h;
Stage #2: 4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide in methanol;dichloromethane at -5; for 5.3 h;

Steps:

1.5 Synthesis of methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine

Step 5
2.15 ml (11.6 mMol) Sodium methoxide in methanol were added over 30 minutes to a suspension of 0.85 g (4.6 mMol) N-bromosuccinimide in 5.0 ml dichloromethane cooled to -5° C.
The reaction mixture was stirred 16 hours at -5° C.
Still at this temperature, a solution of 1.0 g (3.1 mMol) 6-(4-methyl-piperazin-1-yl)-4-o-tolyl-nicotinamide in 5.0 ml methanol was added over 20 minutes and stirred for 5 hours. 7.1 ml (7.1 mMol) Aqueous HCl 1N and 20 ml dichloromethane were added.
The phases were separated and the organic phase was washed with deionized water.
The aqueous phases were extracted with dichloromethane, brought to pH=8 with aqueous NaOH 1N and further extracted with dichloromethane.
The latter organic extracts were combined, dried (Na2SO4) and concentrated to yield 1.08 g (quant.) [6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-carbamic acid methyl ester as a grey foam. MS (ISP): 341 (M+H+, 100), 284 (35).

References:

US8426450,2013,B1 Location in patent:Page/Page column 26

Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate Related Search:

广宁县| 江华| 孝感市| 奈曼旗| 徐汇区| 井冈山市| 阿城市| 章丘市| 渑池县| 宁都县| 浮山县| 吴堡县| 辽阳县| 泗洪县| 正阳县| 锡林浩特市| 砚山县| 湄潭县| 贺兰县| 水富县| 故城县| 聂荣县| 涟源市| 新邵县| 杭州市| 河津市| 怀仁县| 汽车| 嘉荫县| 依兰县| 青河县| 灵武市| 增城市| 曲阳县| 历史| 玉林市| 乡宁县| 叙永县| 曲周县| 普定县| 普兰县|