4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide synthesis
- Product Name:4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide
- CAS Number:364-62-5
- Molecular formula:C14H22ClN3O2
- Molecular Weight:299.8
7232-21-5
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$39.00/10g
364-62-5
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$5.00/25mg
Yield:364-62-5 65%
Reaction Conditions:
with sodium hydrogencarbonate in methanol;dichloromethane
Steps:
2.1 Synthesis of 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide (3):
4-amino-5 -chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide hydrochloride 1 (5.0 g,14.9 mmol) was taken in DCM:MeOH (30 mL, 9.5:0.5) in a 250 mL separating funnel. To it was added saturated NaHCO3 solution (50 mL). The extracted organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. This was finally dried under high vaccum which affored a white solid (2.9 g, 65%). This was then used in the next step without any further purification.
References:
RAO M, Surya WO2017/37566, 2017, A1 Location in patent:Paragraph 00169
7206-70-4
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100-36-7
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364-62-5
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7206-70-4
265 suppliers
$24.89/5g
364-62-5
307 suppliers
$5.00/25mg
201230-82-2
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364-62-5
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$5.00/25mg
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364-62-5
307 suppliers
$5.00/25mg