一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List (5-IODO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
375853-79-5

(5-IODO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER synthesis

1synthesis methods
20511-12-0 Synthesis
2-Amino-5-iodopyridine

20511-12-0
458 suppliers
$6.00/1g

24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
859 suppliers
$13.50/25G

-

Yield:375853-79-5 81%

Reaction Conditions:

Stage #1: 2-amino-5-iodopyridine;di-tert-butyl dicarbonatewith lithium hexamethyldisilazane in tetrahydrofuran at 0 - 20; for 16 h;
Stage #2: with ammonium chloride in tetrahydrofuran;water;

Steps:

A.i

Preparation of [5-(4-[1,2,3]triazol-1-yl-butyl)-pyridin-2-yl]-carbamic acid tert-butyl ester i) (5-Iodo-pyridin-2-yl)-carbamic acid tert-butyl ester A solution of 26.72 mL of a 1 M solution of bis-trimethylsilyl lithiumamide in THF was added to a solution of 5-iodo-pyridin-2-ylamine (3 g, 13.36 mmol) in anhydrous THF (30 ml) at 0° C. After warming to r.t. a solution of di-tert-butyl dicarbonate (2.77 g, 12.69 mmol) in THF was added and stirring continued for 16 h. The mixture was quenched with ammonium chloride solution and extracted with ethyl acetate. The extract was washed with brine, dried over Na2SO4 and concentrated. The crude product was washed with diethyl ether yielding (5-iodo-pyridin-2-yl)-carbamic acid tert-butyl ester as light orange solid. Yield 3.45 g, (81%) MS: M=264.7 (ESI+, M-tBu) 1H-NMR(400 MHz, CDCl3): δ=1.55 (s, 9H), 7.84 (d, 1H), 7.90 (d, 1H), 8.47 (s, 1H), 8.49 (s, 1H)

References:

US2006/63812,2006,A1 Location in patent:Page/Page column 16

(5-IODO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Related Search:

尼木县| 恩平市| 新平| 合江县| 岳池县| 珠海市| 河间市| 博客| 德阳市| 五常市| 秭归县| 闽侯县| 新干县| 钟祥市| 武安市| 富民县| 乐东| 邮箱| 独山县| 大关县| 江门市| 弥渡县| 襄城县| 金川县| 昭平县| 奉节县| 高要市| 郑州市| 蒙城县| 乌兰察布市| 儋州市| 德兴市| 磴口县| 务川| 合江县| 安徽省| 临潭县| 揭东县| 河东区| 莱阳市| 大港区|