3-CHLORO-2-(CHLOROMETHYL)-4-METHYLQUINOLINE HYDROCHLORIDE synthesis
1synthesis methods
- Product Name:3-CHLORO-2-(CHLOROMETHYL)-4-METHYLQUINOLINE HYDROCHLORIDE
- CAS Number:37781-33-2
- Molecular formula:C11H9Cl2N
- Molecular Weight:226.1
Yield:37781-33-2 76%
Reaction Conditions:
Stage #1: 2-aminoacetophenone;1,3-Dichloroacetonewith chloro-trimethyl-silane in N,N-dimethyl-formamide at 0;Heating;Sealed;Fridlaender reaction;
Stage #2: with water in N,N-dimethyl-formamide at 20; for 1 h;Sonication;Fridlaender reaction;
References:
Ryabukhin, Sergey V.;Naumchik, Vasiliy S.;Plaskon, Andrey S.;Grygorenko, Oleksandr O.;Tolmachev, Andrey A. [Journal of Organic Chemistry,2011,vol. 76,# 14,p. 5774 - 5781] Location in patent:experimental part