4,4'-(1-METHYLENE) BIS-BENZONITRILE synthesis
- Product Name:4,4'-(1-METHYLENE) BIS-BENZONITRILE
- CAS Number:10466-37-2
- Molecular formula:C15H10N2
- Molecular Weight:218.25
Yield:10466-37-2 80%
Reaction Conditions:
Stage #1: para-methylbenzonitrilewith n-butyllithium in tetrahydrofuran at -60; for 0.5 h;
Stage #2: 4-Cyanochlorobenzene in tetrahydrofuran at -60 - -50; for 2 h;Reagent/catalyst;Temperature;
Steps:
2 Preparation of 4,4-dicyanodiphenylmethane (Compound 3)
23.4 g (0.2 mol) of p-methylbenzonitrile was dissolved in 40 ml of tetrahydrofuran, A solution of n-butyllithium in tetrahydrofuran (128 ml, 2.5 M / L) was added dropwise at -60 ° C, After the dropwise addition, stirring was continued for half an hour. At this temperature, A solution of 32.9 g (0.24 mol) of p-chlorobenzonitrile in tetrahydrofuran (80 ml) was added dropwise, Control the reaction temperature at -60°C ~-50°C , Drip continued to respond 2h. And then slowly rose to room temperature, the end of the reaction, adding water, precipitation of solid, filter, filter cake washed, dry, light yellow products 35.1g, yield 80%.
References:
CN105801501,2016,A Location in patent:Paragraph 0052; 0053
112809-51-5
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