4-Acetylbenzoic acid synthesis
- Product Name:4-Acetylbenzoic acid
- CAS Number:586-89-0
- Molecular formula:C9H8O3
- Molecular Weight:164.16
122-00-9
702 suppliers
$5.00/25g
586-89-0
302 suppliers
$10.00/1g
Yield:586-89-0 92.1%
Reaction Conditions:
with carbon tetrabromide;oxygen in acetonitrile at 20; for 60 h;UV-irradiation;
Steps:
27 Example 27Compound 16
4-acetyltoluene (67 mg, 0.5 mmol),Carbon tetrabromide (16mg, 0.05mmol) was addedInto a reaction flask filled with oxygen,Plug in an oxygen balloon, and finally add 10ml of acetonitrile.Reaction at 400nm LED wavelength and room temperature for 60h,After the reaction, the solvent was distilled off under reduced pressure.Add excess 2mol / L sodium hydroxide solution for washing,Adjust the pH to about 10 ~ 11,The aqueous phase was extracted multiple times with ethyl acetate,Then add 2mol / L of dilute hydrochloric acid to the water phase,Adjust the pH to 1-2,The aqueous phase was extracted again with ethyl acetate several times,Evaporate the ethyl acetate and dry,That gives compound 16,The yield was 92.1%.
References:
Zhejiang University of Technology;Li Xiaoqing;Zheng Kun;Xu Xiangsheng CN110563571, 2019, A Location in patent:Paragraph 0158; 0159; 0160; 0161
124-38-9
728 suppliers
$175.00/23402
99-90-1
487 suppliers
$6.00/25g
586-89-0
302 suppliers
$10.00/1g
619-64-7
268 suppliers
$6.00/10g
586-89-0
302 suppliers
$10.00/1g