4'-AMINOBUTYROPHENONE synthesis
- Product Name:4'-AMINOBUTYROPHENONE
- CAS Number:1688-71-7
- Molecular formula:C10H13NO
- Molecular Weight:163.22
64-17-5
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$10.00/50g
100-19-6
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$5.00/5g
1688-71-7
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$30.00/500mg
99-92-3
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$6.00/10g
Yield: 21 %Chromat. ， 69 %Chromat.
Reaction Conditions:
with sodium hydroxide at 120; for 24 h;
Steps:
Reduction and chain elongation
General procedure: A mixture of 4-nitroacetophenone (0.83 g,5 mmol), NaOH (0.6 g), Pd/MgLaO (0.2 g) and the appropriate alcohol (10 ml)were stirred at 120 C (bath temperature) for 24 h. The mixture was filtered,the solid was washed with MeOH and the filtrate was concentrated in vacuum.The residue was dissolved in Et2O and H2O. Dilute HCl (25%) was added untilpH 1. The two phases were separated and the aqueous phase basified to pH 8by adding NaHCO3. The aqueous phase was extracted with Et2O (2 50 mL).The organic phase was dried over Na2SO4 and concentrated in vacuum. Theproducts were purified by column chromatography
References:
Németh, János;Kiss, árpád;Hell, Zoltán [Tetrahedron Letters,2013,vol. 54,# 45,p. 6094 - 6096]
4981-64-0
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$48.00/1g
1688-71-7
62 suppliers
$30.00/500mg
64-17-5
892 suppliers
$10.00/50g
100-19-6
311 suppliers
$5.00/5g
1688-71-7
62 suppliers
$30.00/500mg
1009-11-6
207 suppliers
$11.00/5g
1688-71-7
62 suppliers
$30.00/500mg