4-Aminotetrahydropyran synthesis
- Product Name:4-Aminotetrahydropyran
- CAS Number:38041-19-9
- Molecular formula:C5H11NO
- Molecular Weight:101.15
4-Aminotetrahydropyran can be synthesized from 4-cyanotetrahydropyran and sodium hydroxide solution as raw materials to synthesize 4-formamide tetrahydropyran, and then slowly add sodium hypochlorite solution to 4-formamide tetrahydropyran. Synthesized by decarboxylation.
29943-42-8
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$5.00/1g
38041-19-9
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$6.00/1g
Yield:38041-19-9 90 %Chromat.
Reaction Conditions:
with ammonium hydroxide;nickel-aluminum alloy;water at 20; for 2 h;Sonication;Green chemistry;
Steps:
Reductive Amination of Ketones in NH4OH; Cyclohexylamine; Typical Procedure
General procedure: Ni-Al alloy (200 mg) and cyclohexanone (35 μL, 0.34 mmol) were suspended in 28-30% NH4OH (3 mL) and sonicated (Branson 1510MTH ultrasonic bath) for 2 h. After the completion of the reaction, the excess alloy and solid by-products were removed by filtration. The filtrate was extracted with EtOAc (2 × 2 mL). The organic extracts were combined and dried over anhyd Na2SO4. The solvent was removed in vacuo and the crude product was purified by flash chromatography.
References:
Sch?fer, Christian;Ni?anci, Bilal;Bere, Matthew P.;Da?tan, Arif;T?r?k, Béla [Synthesis,2016,vol. 48,# 18,art. no. SS-2016-M0224-OP,p. 3127 - 3133]
61128-73-2
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38041-19-9
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344329-76-6
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$7.00/250mg
38041-19-9
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625126-73-0
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38041-19-9
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2081-44-9
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38041-19-9
331 suppliers
$6.00/1g