Yield:289662-11-9 90.59%

Reaction Conditions:

in N,N-dimethyl-formamide at 25; for 12 h;

Steps:

2

To a mixture of 3, 5-dichloro-4-hydroxy-benzaldehyde (9 g, 47.12 mmol, 1 eq) and K2CO3 (13.02 g, 94.24 mmol, 2 eq) in DMF (100 mL) was added BnBr (9.67 g, 56.54 mmol, 6.72 mL, 1.2 eq) and it was stirred at 25 °C for 12 hr. The reaction mixture was partitioned between H₂O (500 mL) and EtOAc (800 mL). The organic layer was washed with sub-saturated brine (300 mL*3), saturated brine (300 mL), dried overNa2SO4 and concentrated to give a residue. The residue was purified by silica gel column (PE: EtOAc=20: 1 to 5 : 1) to afford 4-benzyloxy- 3, 5-dichloro-benzaldehyde (12 g, 42.68 mmol, 90.59%s yield) as a white solid.

References:

WO2022/58733,2022,A1 Location in patent:Page/Page column 42; 72