(4-bromo-2,5-difluorophenyl)methanol synthesis
- Product Name:(4-bromo-2,5-difluorophenyl)methanol
- CAS Number:486460-26-8
- Molecular formula:C7H5BrF2O
- Molecular Weight:223.01
357405-75-5
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$12.00/250mg
486460-26-8
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$110.00/100mg
Yield:486460-26-8 94.47%
Reaction Conditions:
with sodium tetrahydroborate in methanol at 80; for 0.5 h;
Steps:
1 Synthesis of BDl
NaBH4 (128.38 mg, 3.39 mmol) was added to a solution of 150.00 g Compound BD1- 1 (i.e., 4-bromo-2,5-difluorobenzaldehyde) in MeOH (4.00 mL). The mixture was stirred at 80°C for 30 minutes. TLC indicated Compound BDl-l was consumed completely in this reaction time. An additional compound with a larger polarity than Compound BDl-l was measured. The reaction mixture was concentrated to remove MeOH, then diluted with saturated NaHC03 (4 ml), extracted with DCM (5 mL * 3), the combined organic layer was washed with saturated brine (5 mL * 2), dried over Na2S04, filtered and concentrated to give a residue. The residue was purified by prep-TLC (S1O2, Petroleum ether:Ethyl acetate mixture with a ratio of 3: 1) to afford Compound BDl-2 (143.00 mg, 641.23 τηο, 94.47% yield) as a white solid.
References:
WO2018/75871,2018,A1 Location in patent:Page/Page column 60
28314-82-1
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486460-26-8
65 suppliers
$110.00/100mg
327-51-5
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$5.00/5g
486460-26-8
65 suppliers
$110.00/100mg