4-bromo-2,6-dimethoxyphenol synthesis
- Product Name:4-bromo-2,6-dimethoxyphenol
- CAS Number:70654-71-6
- Molecular formula:C8H9BrO3
- Molecular Weight:233.06
91-10-1
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$7.00/1g
70654-71-6
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$570.00/1g
Yield:70654-71-6 89%
Reaction Conditions:
Stage #1: 1,3-dimethoxy-2-hydroxy-benzenewith sodium hydride in methanol;dichloromethane at -45; for 0.333333 h;Inert atmosphere;
Stage #2: with N-Bromosuccinimide in methanol;dichloromethane at -45 - 45; for 3.5 h;Inert atmosphere;
Steps:
1.1 Step 1:
Under argon protection, compound 2,6-dimethoxyphenol 1 (10 g, 64.86 mmol) was dissolved in dichloromethane (100 mL) and cooled to -45°CThen sodium hydride (0.026 g, 0.645 mmol) dissolved in methanol (1 mL) was slowly added to react for 20 minutes; N-bromosuccinamide (NBS) was added, and after 30 minutes of reaction at 45°C, the reaction was slowly raised to room temperature for 3 hours. Distilled water was added to quench, the organic phase was extracted with dichloromethane, and the product was separated and purified by silica gel column (PE:EtOAc = 4:1, Rf = 0.57) to obtain a white solid product (13.45 g, yield 89%).
References:
CN114773303,2022,A Location in patent:Paragraph 0041-0044
2675-79-8
236 suppliers
$8.00/1g
70654-71-6
26 suppliers
$570.00/1g
