4-BROMO-2-CHLORO-6-METHYLPHENOL synthesis
- Product Name:4-BROMO-2-CHLORO-6-METHYLPHENOL
- CAS Number:7530-27-0
- Molecular formula:C7H6BrClO
- Molecular Weight:221.48
87-64-9
7530-27-0
2-Chloro-6-methylphenol (5 g, 35 mmol) was used as starting material and dissolved in acetic acid (70 mL). Subsequently, N-bromosuccinimide (NBS, 6.2 g, 35 mmol) was added to this solution. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the acetic acid was removed by distillation under reduced pressure. The residue was diluted with ethyl acetate, washed sequentially with saturated sodium carbonate solution and dried over sodium sulfate. Finally, the solvent was removed by reduced pressure distillation to afford the target product 4-bromo-2-chloro-6-methylphenol (4 g, 52% yield), which can be used in subsequent reactions without further purification.
87-64-9
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$9.00/1g
7530-27-0
101 suppliers
$6.00/1g
Yield:7530-27-0 52%
Reaction Conditions:
with N-Bromosuccinimide;acetic acid at 20; for 12 h;
Steps:
5.2 Step 2: 2-Chloro-4-bromo-6-methylphenol (35)
To a solution of 2-chloro-6- methylphenol 34 (5 g, 35 mmol) in AcOH (70 mL) was added NBS (6.2 g, 35 mmol). The solution was stirred at RT for 12 h. AcOH was removed under reduced pressure. The residue was diluted with EtOAc, washed with saturated Na2C03 solution and dried over Na2S04. Removal of the solvents gave compound 35 (4 g, 52%) which was used in the next step without further purification.
References:
WO2017/4609,2017,A1 Location in patent:Paragraph 0219
2362-12-1
199 suppliers
$5.00/1g
7530-27-0
101 suppliers
$6.00/1g