4'-Bromo-2'-fluoroacetanilide synthesis
- Product Name:4'-Bromo-2'-fluoroacetanilide
- CAS Number:326-66-9
- Molecular formula:C8H7BrFNO
- Molecular Weight:232.05
367-24-8
512 suppliers
$15.00/25 g
75-36-5
576 suppliers
$17.92/100G
326-66-9
167 suppliers
$15.00/5 g
Yield: 99%
Reaction Conditions:
with triethylamine in dichloromethane at 0 - 20; for 8 h;
Steps:
To a solution of 4- bromo-2-fluoroaniline (2.0g, 10.51 mmol) in dichloromethane (20 ml) cooled to 0°C, triethylamine ( 2.90 ml, 21.02) was added followed by acetyl chloride ( 0.90 ml, 12.61 mol). After stirring at room temperature for 8h, the reaction mixture was quenched with water, extracted with dichloromethane, dried over sodium sulphate and concentrated to afford the title compound as a off-white solid ( 2.60g, 99%) which was used as such in next step.
References:
RHIZEN PHARMACEUTICALS SA;NAGARATHNAM, Dhanapalan;VAKKALANKA, Swaroop Kumar, V.S.;MUTHUPPALANIAPPAN, Meyyappan;VISWANADHA, Srikant;BABU, Govindarajulu;BHAVAR, Prashant, Kashinath WO2012/151525, 2012, A1 Location in patent:Page/Page column 122
399-31-5
137 suppliers
$10.00/5g
326-66-9
167 suppliers
$15.00/5 g
103-88-8
271 suppliers
$6.00/5g
326-66-9
167 suppliers
$15.00/5 g
367-24-8
512 suppliers
$15.00/25 g
108-24-7
0 suppliers
$14.00/250ML
326-66-9
167 suppliers
$15.00/5 g
348-54-9
430 suppliers
$10.00/1g
326-66-9
167 suppliers
$15.00/5 g